Iconic eccentric-bore .45 ACP pistol can with the lowest sight obstruction of any dedicated .45

The SilencerCo Osprey 45 2.0 is the market-defining .45 ACP suppressor and the reason "offset can" is even a category. Its eccentric design drops the baffle stack below the bore axis instead of centering it, so the can sits low and barely intrudes into the sight picture. On a .45 with standard-height sights you can often still get a usable picture over the top of the tube, where a round can of the same diameter would force a full set of suppressor-height sights. That sight-clearance advantage is the whole point of the Osprey line.
At 9.2 ounces and 8.06 inches it is light for a full-size .45 can, built from an aluminum tube over 17-4 stainless baffles. .45 ACP is naturally subsonic in standard 230-grain loads, so the Osprey turns a full-size 1911 or Glock 21 into a genuinely quiet host, rated around 130 decibels at the ear. Its large internal volume means the baffles rarely need cleaning. Budget for the mount separately: SilencerCo ships the Osprey 2.0 with a disassembly tool, an indexing ring and spring retainer and one piston spring, but no piston, so add a SilencerCo piston in your host thread pitch (and the AC22 fixed barrel spacer if the host has a fixed barrel).
The one real tradeoff is that SilencerCo publishes no full-auto rating for the Osprey, so treat it as a semi-auto pistol and PCC can rather than a subgun workhorse. For the vast majority of .45 shooters, who are running a handgun and not a belt-fed, that is a non-issue, and the sight-clearance benefit is worth more than a full-auto rating they will never use.
Add the SilencerCo Osprey 45 2.0 to your build and see how it enhances your platform.