The 9x19mm Parabellum was designed by Georg Luger in 1901 for the German Navy. The cartridge prioritized lighter bullets at higher velocity, enabling smaller and lighter pistols with higher magazine capacity. The 9mm became the NATO standard pistol cartridge in 1955, and today it is the most widely used handgun cartridge in the world. Over 60% of law enforcement agencies in the United States issue 9mm duty pistols.
The .45 ACP (Automatic Colt Pistol) was developed by John Browning in 1905 and adopted by the U.S. military in 1911 with the iconic M1911 pistol. The cartridge was designed in response to the Philippine-American War, where the .38 Long Colt revolver failed to stop determined attackers. The military demanded a pistol cartridge with "one-shot stopping power," and the .45 ACP's heavy 230-grain bullet traveling at 830 fps delivered that capability. The cartridge served as the U.S. military sidearm caliber for 74 years.
The .380 ACP (also known as 9mm Short or 9x17mm) was designed by Browning in 1908 for the Colt Model 1908 pocket pistol. The cartridge was engineered specifically for compact, blowback-operated pistols where a locked breech was unnecessary. Its moderate pressure (21,500 psi SAAMI max) and shorter case allow simpler, lighter pistol designs that prioritize concealability over raw performance. The .380 shares the same 0.355-inch bullet diameter as 9mm but differs in case length (17.3mm vs 19.15mm) and operating pressure.
The critical inflection point for all three cartridges was the development of modern hollow point ammunition in the 1990s and 2000s. When limited to full metal jacket ammunition, the .45 ACP's larger diameter created objectively larger wound channels. Modern hollow points engineered to expand to 1.5-2x their original diameter eliminated much of this advantage, because a 9mm bullet expanding from 0.355" to 0.60"+ creates a wound channel comparable to a .45 ACP expanding from 0.452" to 0.70". The .380's lower velocity makes reliable expansion more difficult, which is why bullet selection matters most in that caliber.